Like ten million other publishers, I got an email from Google last month. In the email, Google suggested I place 300×250 Adsense units on my site. In exchange, they would include my site in their custom placement packs program. Custom placement packs are selections of individually reviewed sites designed for Google's largest brand advertisers. In other words, they want to show more video ads. I doubt video ads will work well on my site and I'm not too fond of running such a big ad in the content area. But I decided to do a test run on three of my sites. All three sites use the same theme (with different colors).
The results below are based on the first 16 days of January and February. In February, I ran 300×250 ads (top right of content) in place of 468×60 banners (above content in January). So "28%" for the 300×250 stat in the first table means the 300×250 ad resulted in an eCPM increase of 28% compared to the 468×60 ad I ran in January. Keep in mind I'm comparing stats from two different months.
| Site #1 | eCPM |
| 300×250 (top right of content) | +28% |
| 160×600 (left side bar) | +51% |
| Link unit (below header) | -52% |
| Overall | +24% |
| Site #2 | eCPM |
| 300×250 (top right of content) | +70% |
| 160×600 (left side bar) | +16% |
| Link unit (below header) | +19% |
| 300×250 (bottom of content) | -22% |
| Overall | +25% |
| Site #3 | eCPM |
| 300×250 (top right of content) | +16% |
| 160×600 (left side bar) | -13% |
| Link unit (below header) | -10% |
| Overall | -4% |
As you can see, the 300×250 ads resulted in an overall increase for two of my sites. However, the medium rectangle ad resulted in a slight decrease for the third site, which happens to be my main site. I'm not going to pull the new ad size yet. I'm going to let it run a little longer to see if being included in Google's custom placement packs program makes a difference.

Good Idea, I will do it.
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http://www.thailandhub.net
I used the largerectangle ads in a wonderful template from blogger
The bigger the better. The 300X250 adsense ad unit seems like a good idea to me. I am about to create some more adsense sites so I am going to give this size a go.
Links are useless IMO. They pay very little compared to the blocks. My experience shows that one click on the 300X250 is worth 10 clicks on link blocks.